Magnesium plays an essential role in a large number of important cellular reactions: it contributes to bone mineralization and development and to neuromuscular excitability; together with calcium, it is involved in many enzyme systems; it is involved in the bio-synthesis of proteins, fats and nucleic acids. Magnesium enters the glycolysis process which converts glucose into energy and is essential for muscle contraction and smooth muscle relaxation; it is closely related to the resistance of fatigue, stress and onset of cramps resistance.